Centrosome Declustering: An Anticancer Strategy

Centrosome clustering  is a phenomenon associated with tumorigenesis. The clustering of centrosomes in cancer cells enables them to form a pseudo-bipolar mitotic spindle.

Centrosme clustering: An anticancer strategy

 

In cases which are very rare, this mechanism fails resulting in declustered centrosomes leading to a multipolar spindle. Spindle multipolarity in turn leads to mitotic arrest and finally cell death.

Centrosome DeClustering Review

Enhanced by Zemanta

Incoming terms:

Leave a Reply

Your email address will not be published. Required fields are marked *