Centrosome Declustering: An Anticancer Strategy

Centrosome clustering  is a phenomenon associated with tumorigenesis. The clustering of centrosomes in cancer cells enables them to form a pseudo-bipolar mitotic spindle.

Centrosme clustering: An anticancer strategy


In cases which are very rare, this mechanism fails resulting in declustered centrosomes leading to a multipolar spindle. Spindle multipolarity in turn leads to mitotic arrest and finally cell death.

Centrosome DeClustering Review

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