Di-substituted Noscapine Analogs as Potent Anticancer Agents

Noscapine is an opium-derived kinder and gentler microtubule affecting drug, currently in clinical trials for cancer chemotherapy. Here, we report the synthesis of four potent di-substituted derivatives of noscapine and their effect on Prostate Cancer and Breast cancer cells. These have higher tubulin binding than noscapine and affect its polymerization. The equilibrium dissociation constant between tubulin and new compounds is comparable to parent analog. These […]

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New Synthesis of ‘FMCA’: A potential Anti-HBV Drug Candidate

A new and potent anti-HBV drug candidate has been discovered by our research group here at Drug Discovery Group (College of Pharmacy, Department of Pharmaceutical and Biomedical Sciences) of the University of Georgia.   FMCA stands for Fluoro and Methylene substituted derivative of Carbocyclic Adenosine. It has a 2’-F substitution and 6’ exocyclic methylene group which distinguishes it from Aristeromycin, […]

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