Di-substituted Noscapine Analogs as Potent Anticancer Agents

rc-bmcl-2015

Noscapine is an opium-derived kinder and gentler microtubule affecting drug, currently in clinical trials for cancer chemotherapy. Here, we report the synthesis of four potent di-substituted derivatives of noscapine and their effect on Prostate Cancer and Breast cancer cells. These have higher tubulin binding than noscapine and affect its polymerization. The equilibrium dissociation constant between tubulin and new compounds is comparable to parent analog. These […]

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