Di-substituted Noscapine Analogs as Potent Anticancer Agents

Noscapine is an opium-derived kinder and gentler microtubule affecting drug, currently in clinical trials for cancer chemotherapy. Here, we report the synthesis of four potent di-substituted derivatives of noscapine and their effect on Prostate Cancer and Breast cancer cells. These have higher tubulin binding than noscapine and affect its polymerization. The equilibrium dissociation constant between tubulin and new compounds is comparable to parent analog. These […]

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In Tetrahedron Letters ‘Hydrastine’ reported as ‘Noscapine’

Recently, I came across a paper in reputed weekly chemistry journal, Tetrahedron Letters. It was describing short synthesis of Noscapine and some other natural alkaloids. However, while carefully looking at the structure I found that they have synthesized a molecule which is not Noscapine. When I did a SciFinder investigation for the same I confirmed the molecule synthesized by them […]

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The anti-cancer activity of Noscapine: A Review

Image via Wikipedia Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, noscapine is not sedative and has been used as antitussive drug in various countries. Recently, it has been introduced as an anti-mitotic agent. This drug can be used orally.When the resistance to other anti-cancer drugs such as paclitaxel menifests, noscapine […]

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