Nucleoside-Prodrug Synthesis: Chiral & Non Chiral Reagents

Prodrug-Syntehsis

Since the development of the Pro-drug strategy for the anti viral nucleosides for the treatment of HIV by Christopher McGuigan in 1993, there have been various attempts in designing a reagent for the chiral pro drug synthesis. Since the market debut of Gilead’s Blockbuster drug the reagent (shown as Chiral reagent in the graphics below) has been made commercially available […]

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