Nucleoside-Prodrug Synthesis: Chiral & Non Chiral Reagents

Since the development of the Pro-drug strategy for the anti viral nucleosides for the treatment of HIV by Christopher McGuigan in 1993, there have been various attempts in designing a reagent for the chiral pro drug synthesis.

Since the market debut of Gilead’s Blockbuster drug the reagent (shown as Chiral reagent in the graphics below) has been made commercially available from various chemical vendors including sigma-aldrich. The reagent’s CAS # is 1334514-02-8. I hope this information would be useful for researchers looking for the particular reagent and those working in related area of research.